レビス インスリン-マウス(RTU)  (AKRIN-011RU) / Mouse Insulin ELISA KIT (RTU)

 Original reports

# Caffeic acid ameliorates hepatic steatosis and reduces ER stress in high fat diet-induced obese mice by regulating autophagy.
Kim HM, Kim Y, Lee ES, Huh JH, Chung CH.
Nutrition. 2018 Nov;55-56:63-70.

# Homocysteine supplementation ameliorates steatohepatitis induced by a choline-deficient diet in mice.
Minami S, Miura K, Ishioka M, Morimoto N, Isoda N, Yamamoto H, Iijima K.
Hepatol Res. 2018 Jul 26.

# Dual CCR2/5 Antagonist Attenuates Obesity-Induced Insulin Resistance by Regulating Macrophage Recruitment and M1/M2 Status.
Huh JH, Kim HM, Lee ES, Kwon MH, Lee BR, Ko HJ, Chung CH.
Obesity (Silver Spring). 2018 Feb;26(2):378-386.

# Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet.
Kim KE, Jeong EA, Shin HJ, Lee JY, Choi EB, An HS, Park KA, Jin Z, Lee DK, Horvath TL, Roh GS.
Biochem Biophys Res Commun. 2019 Jan 1;508(1):123-129.

# HM47118A, a novel insulinotropic GPR119 agonist and potential oral antidiabetic agent.
Hun Song T, Don Lee S, Eun Ha Y, Jin Choi K, Hyun Lee S, Kim YH, Hyun Suh K, Chun YJ.
Diabetes Res Clin Pract. 2019 Jan 11. pii: S0168-8227(18)31385-8.

# SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels.
Suga T, Kikuchi O, Kobayashi M, Matsui S, Yokota-Hashimoto H, Wada E, Kohno D, Sasaki T, Takeuchi K, Kakizaki S, Yamada M, Kitamura T.
Mol Metab. 2019 Jan;19:1-12.

# Metabolomic Analysis of Diet-Induced Obese Mice Supplemented with Eicosapentaenoic Acid.
Nishitani S, Fukuhara A, Jinno Y, Kawano H, Yano T, Otsuki M, Shimomura I.
Exp Clin Endocrinol Diabetes. 2018 Dec 10.

# Glucosamine induces increased musclin gene expression through endoplasmic reticulum stress-induced unfolding protein response signaling pathways in mouse skeletal muscle cells.
Guo Q, Hu H, Zhou Y, Yan Y, Wei X, Fan X, Yang D, He H, Oh Y, Chen K, Wu Q, Liu C, Gu N.
Food Chem Toxicol. 2018 Dec 30;125:95-105.

# Metabolism of Natural Highly Unsaturated Fatty Acid, Tetracosahexaenoic Acid (24:6n-3), in C57BL/KsJ-db/db Mice.
Gotoh N, Nagao K, Ishida H, Nakamitsu K, Yoshinaga K, Nagai T, Beppu F, Yoshinaga-Kiriake A, Watanabe H, Yanagita T.
J Oleo Sci. 2018 Dec 1;67(12):1597-1607.

# Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice.
Nammo T, Udagawa H, Funahashi N, Kawaguchi M, Uebanso T, Hiramoto M, Nishimura W, Yasuda K.
Diabetologia. 2018 Dec;61(12):2608-2620.

# Adenosine stimulates hepatic glycogenolysis via adrenal glands-liver crosstalk in mice.
Tadaishi M, Toriba Y, Shimizu M, Kobayashi-Hattori K.
PLoS One. 2018 Dec 21;13(12):e0209647.

# The impact of hepatic HSP72 on insulin signaling.
Kitano S, Kondo T, Matsuyama R, Ono K, Goto R, Takaki Y, Hanatani S, Sakaguchi M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.
Am J Physiol Endocrinol Metab. 2018 Dec 11.

# Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channels.
Hwang HJ, Park KS, Choi JH, Cocco L, Jang HJ, Suh PG.
J Cell Physiol. 2018 Nov;233(11):8701-8710.

# Glucose-dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice.
Shimazu-Kuwahara S, Kanemaru Y, Harada N, Ikeguchi E, Ueda Y, Yamane S, Murata Y, Yasoda A, Kieffer TJ, Inagaki N.
J Diabetes Investig. 2018 Nov 19.

# Low-carbohydrate high-protein diet diminishes the insulin response to glucose load via suppression of SGLT-1 in mice.
Higashida K, Terada S, Li X, Inoue S, Iida N, Kitai S, Nakai N.
Biosci Biotechnol Biochem. 2018 Oct 25:1-7.

# Characteristics of Bone Strength and Metabolism in Type 2 Diabetic Model Nagoya Shibata Yasuda Mice.
Tanaka H, Miura T, Yamashita T, Yoneda M, Takagi S.
Biol Pharm Bull. 2018 Oct 1;41(10):1567-1573.

# Bisphenol A and octylphenol exacerbate type 1 diabetes mellitus by disrupting calcium homeostasis in mouse pancreas.
Ahn C, Kang HS, Lee JH, Hong EJ, Jung EM, Yoo YM, Jeung EB.
Toxicol Lett. 2018 Oct 1;295:162-172.

# Transcriptional factor Pdx1 is involved in age-related GIP hypersecretion in mice.
Ikeguchi E, Harada N, Kanemaru Y, Sankoda A, Yamane S, Iwasaki K, Imajo M, Murata Y, Suzuki K, Joo E, Inagaki N.
Am J Physiol Gastrointest Liver Physiol. 2018 Aug 1;315(2):G272-G282.

# Effects of lobeglitazone on insulin resistance and hepatic steatosis in high-fat diet-fed mice
Bong-H C, Zhen J, Chin-ok Y, Juhong O, Eun A J, Jong Y L, Kyung-ah P, Kyung E K, Jung E L, Hyun-Jin K, Jong R H,Gu S R,
PLOS: July 6, 2018

# Characteristics of bone strength and metabolism in type 2 diabetic model Tsumura, Suzuki, Obese Diabetes mice.
Tanaka H, Yamashita T, Yoneda M, Takagi S, Miura T.
Bone Rep. 2018 Jul 21;9:74-83.

# Reintroducing testosterone in the db/db mouse partially restores normal glucose metabolism and insulin resistance in a leptin-independent manner.
Yabiku K, Nakamoto K, Tokushige A.
BMC Endocr Disord. 2018 Jun 13;18(1):38.

# Sterol O-acyltransferase 1 deficiency improves defective insulin signaling in the brains of mice fed a high-fat diet.
Xu N, Meng H, Liu TY, Feng YL, Qi Y, Zhang DH, Wang HL.
Biochem Biophys Res Commun. 2018 May 5;499(2):105-111.

# Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver.
Tobita H, Sato S, Yazaki T, Mishiro T, Ishimura N, Ishihara S, Kinoshita Y.
Mol Med Rep. 2018 May;17(5):6840-6846.

# Discovery of a long-acting glucagon-like peptide-1 analog with enhanced aggregation propensity.
Takeuchi M, Okamoto M, Okamoto R, Kinoshita H, Yamaguchi Y, Watanabe N
Peptides. 2018 Apr;102:8-15.

# Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes.
Taguchi K, Bessho N, Hasegawa M, Narimatsu H, Matsumoto T, Kobayashi T.
Hypertens Res. 2018 Apr;41(4):263-274.

# Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets.
Kim KE, Jeong EA, Lee JY, Yi CO, Park KA, Jin Z, Lee JE, Horvath TL, Roh GS.
Biochem Biophys Res Commun. 2018 May 23;499(4):1025-1031.

# Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice.
Takenouchi Y, Ohtake K, Nobe K, Kasono K.
Lipids Health Dis. 2018 May 22;17(1):118.

# Treatment with specific soluble factors promotes the functional maturation of transcription factor-mediated, pancreatic transdifferentiated cells.
Motoyama H, Kobayashi A, Yokoyama T, Shimizu A, Sakai H, Notake T, Fukushima K, Miyagawa SI.
PLoS One. 2018 May 16;13(5):e0197175.

# Cucurbitane Triterpenoids from the Fruits of Momordica Charantia Improve Insulin Sensitivity and Glucose Homeostasis in Streptozotocin-Induced Diabetic Mice.
Han JH, Tuan NQ, Park MH, Quan KT, Oh J, Heo KS, Na M, Myung CS.
Mol Nutr Food Res. 2018 Apr;62(7):e1700769.

# Discovery of a long-acting glucagon-like peptide-1 analog with enhanced aggregation propensity.
Takeuchi M, Okamoto M, Okamoto R, Kinoshita H, Yamaguchi Y, Watanabe N.
Peptides. 2018 Apr;102:8-15.

# Metabolic effects of Tofogliflozin are efficiently enhanced with appropriate dietary carbohydrate ratio and are distinct from carbohydrate restriction.
Ito S, Hosaka T, Yano W, Itou T, Yasumura M, Shimizu Y, Kobayashi H, Nakagawa T, Inoue K, Tanabe S, Kondo T, Ishida H.
Physiol Rep. 2018 Mar;6(5).

# Gastric inhibitory polypeptide receptor antagonist, SKL-14959, suppressed body weight gain on diet-induced obesity mice.
Nakamura T, Tanimoto H, Mizuno Y, Okamoto M, Takeuchi M, Tsubamoto Y, Noda H.
Obes Sci Pract. 2018 Mar 25;4(2):194-203.

# Rice bran protein hydrolysates attenuate diabetic nephropathy in diabetic animal model.
Boonloh K, Lee ES, Kim HM, Kwon MH, Kim YM, Pannangpetch P, Kongyingyoes B, Kukongviriyapan U, Thawornchinsombut S, Lee EY, Kukongviriyapan V, Chung CH.
Eur J Nutr. 2018 Mar;57(2):761-772.

# Sitosterol prevents obesity-related chronic inflammation.
Kurano M, Hasegawa K, Kunimi M, Hara M, Yatomi Y, Teramoto T, Tsukamoto K.
Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Feb;1863(2):191-198.

# Effect of N-Acetylcysteine on Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in a Rat Model of Insulin Resistance.
Zukowski P, Maciejczyk M, Matczuk J, Kurek K, Waszkiel D, ?endzian-Piotrowska M, Zalewska A.
Oxid Med Cell Longev. 2018 Jan 30;2018:6581970.

# Impaired peripheral nerve regeneration in type-2 diabetic mouse model.
Pham VM, Tu NH, Katano T, Matsumura S, Saito A, Yamada A, Furue H, Ito S.
Eur J Neurosci. 2018 Jan;47(2):126-139.

# Role of Supplementary Selenium on the Induction of Insulin Resistance and Oxidative Stress in NSY Mice Fed a High Fat Diet.
Murano K, Ogino H, Okuno T, Arakawa T, Ueno H.
Biol Pharm Bull. 2018;41(1):92-98.

# A Tryptophan Hydroxylase Inhibitor Increases Hepatic FGF21 Production and Decreases Hepatic Gluconeogenesis Independently of Insulin in db/db Mice
Katsunori Nonogaki, Takao Kaji, Mari Murakami
Neuropsychiatry (London) (2018) 8(4), 1476?1481

# Camellia japonica Seeds Extract SuppressesLipid-induced Hypertriglyceridemia and Fat Accumulation in Mice.
Ochiai M, Nozaki T, Kato M, Ishihara KO
J Oleo Sci. 2018;67(12):1563-1569.

# Effect of Seleno-L-methionine on Oxidative Stress in the Pancreatic Islets of a Short-Term Induced Diabetic Mouse Model in Insufficient Selenium Status.
Ueno H, Shimizu R, Okuno T, Ogino H, Arakawa T, Murano K, Nakamuro K.
Biol Pharm Bull. 2018;41(1):80-85.

# Deficiency of COX7RP, a mitochondrial supercomplex assembly promoting factor, lowers blood glucose level in mice.
Shiba S, Ikeda K, Horie-Inoue K, Nakayama A, Tanaka T, Inoue S.
Sci Rep. 2017 Aug 8;7(1):7606.

# Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.
Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M.
Diabetologia. 2017 Jun;60(6):1138-1151. 

# α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2.
Kim HM, Kim YM, Huh JH, Lee ES, Kwon MH, Lee BR, Ko HJ, Chung CH.
PLoS One. 2017 Jun 9;12(6):e0179204. 

# Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.
Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M.
Diabetologia. 2017 Jun;60(6):1138-1151.

# Anti-diabetic effects of luteolin and luteolin-7-O-glucoside on KK-A(y) mice.
Zang Y, Igarashi K, Li Y.
Biosci Biotechnol Biochem. 2016 Aug;80(8):1580-6.

# Insulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis.
Lee JM, Seo WY, Han HS, Oh KJ, Lee YS, Kim DK, Choi S, Choi BH, Harris RA, Lee CH, Koo SH, Choi HS
Diabetes. 2016 Jan;65(1):62-73.

 # Metabolomics-based search for therapeutic agents for non-alcoholic steatohepatitis
Yoshihiko Terashima, Shin Nishiumi , Akihiro Minami, Yuki Kawano, Namiko Hoshi, Takeshi Azuma, Masaru Yoshida,
Archives of Biochemistry and Biophysics, Vol.555–556, p55-65, Aug 2014.

# Indirect Effects of Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 on the Peripheral Circadian Clocks in Mice
Hitoshi Ando ,  Kentarou Ushijima,  Akio Fujimura
PLoS One. 2013 Nov 15;8(11):e81119.

# Effects of Two Types of Non-Digestible Carbohydrates on Energy Metabolism in Mice 
 Akiyama, Takashi; Nakatani, Sachie; Kobata, Kenji; Wada, Masahiro
 Journal of Chitin and Chitosan Science, Vol.2, Number 3, p223-232(10), Sep 2014.

# Cinnamtannin A2, a Tetrameric Procyanidin, Increases GLP-1 and Insulin Secretion in Mice
Yamashita Y, Okabe M, Natsume M, Ashida H.
Bioscience, Biotechnology, and Biochemistry , Vol.77(4), 2013

 

 

 

レビス インスリン-マウスT  (AKRIN-011T) / Mouse Insulin ELISA KIT

Original reports

# Endoplasmic Reticulum Stress in Mice Increases Hepatic Expression of Genes Carrying a Premature Termination Codon via a Nutritional Status-Independent GRP78-Dependent Mechanism.
Harada N, Okuyama M, Yoshikatsu A, Yamamoto H, Ishiwata S, Hamada C, Hirose T, Shono M, Kuroda M, Tsutsumi R, Takeo J, Taketani Y, Nakaya Y, Sakaue H.
J Cell Biochem. 2017 Nov;118(11):3810-3824.

# Effects of β-Glucan Content and Pearling of Barley in Diet-Induced Obese Mice
Seiichiro Aoe, Yasunori Ichinose, Noriko Kohyama, Kozo Komae, Asuka Takahashi, Toji Yoshioka, and Takashi Yanagisawa.
Posted online on 27 Sep 2017. https://doi.org/10.1094/CCHEM-04-17-0083-R

# 10-Hydroxy-2-decenoic acid, a natural product, improves hyperglycemia and insulin resistance in obese/diabetic KK-Ay mice, but does not prevent obesity
Risa WATADANI,  Jun KOTOH,  Daiki SASAKI,  Azusa SOMEYA,  Kozo MATSUMOTO,  Akihiko MAEDA
Journal of Veterinary Medical Science, Vol. 79 (2017)  No. 9 Sept, p.1596-1602

# S-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic β-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing β-Cell Function in Male Mice.
Horiuchi H, Usami A, Shirai R, Harada N, Ikushiro S, Sakaki T, Nakano Y, Inui H, Yamaji R.
J Nutr. 2017 Sep;147(9):1631-1639.

# Pathological and gene expression analysis of a polygenic diabetes model, NONcNZO10/LtJ mice.
Hirata T, Yoshitomi T, Inoue M, Iigo Y, Matsumoto K, Kubota K, Shinagawa A.
Gene. 2017 Sep 20;629:52-58. 

# Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis.
Taguchi K, Hida M, Hasegawa M, Narimatsu H, Matsumoto T, Kobayashi T.
Sci Rep. 2017 Aug 16;7(1):8436.

# Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1.
Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H.
PLoS One. 2017 Aug 10;12(8):e0181052.

# Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice.
E S, Yamamoto K, Sakamoto Y, Mizowaki Y, Iwagaki Y, Kimura T, Nakagawa K, Miyazawa T, Tsuduki T.
J Clin Biochem Nutr. 2017 Jul;61(1):47-52.

# Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice.
Kubo H, Hoshi M, Matsumoto T, Irie M, Oura S, Tsutsumi H, Hata Y, Yamamoto Y, Saito K
Lipids Health Dis. 2017 Jun 3;16(1):106.

# Moringa oleifera from Cambodia Ameliorates Oxidative Stress, Hyperglycemia, and Kidney Dysfunction in Type 2 Diabetic Mice.
Tang Y, Choi EJ, Han WC, Oh M, Kim J, Hwang JY, Park PJ, Moon SH, Kim YS, Kim EK.
J Med Food. 2017 May;20(5):502-510.

# 4μ8C Inhibits Insulin Secretion Independent of IRE1α RNase Activity.
Sato H, Shiba Y, Tsuchiya Y, Saito M, Kohno K.
Cell Struct Funct. 2017 May 3;42(1):61-70

 # Inhibition of Gastric Inhibitory Polypeptide Receptor Signaling in Adipose Tissue Reduces Insulin Resistance and Hepatic Steatosis in High-Fat Diet-Fed Mice.
Joo E, Harada N, Yamane S, Fukushima T, Taura D, Iwasaki K, Sankoda A, Shibue K, Harada T, Suzuki K, Hamasaki A, Inagaki N.
Diabetes. 2017 Apr;66(4):868-879.

# Prevention and treatment effect of evogliptin on hepatic steatosis in high-fat-fed animal models.
Kim MK, Chae YN, Ahn GJ, Shin CY, Choi SH, Yang EK, Sohn YS, Son MH
Arch Pharm Res. 2017 Feb;40(2):268-281.

# Royal jelly improves hyperglycemia in obese/diabetic KK-Ay mice.
Mei YOSHIDA,  Kaori HAYASHI,  Risa WATADANI,  Yoshiyasu OKANO,  Keiya TANIMURA,  Jun KOTOH,  Daiki SASAKI,  Kozo MATSUMOTO,  Akihiko MAEDA
Journal of Veterinary Medical Science, Vol. 79 (2017)  No. 2 February p. 299-307

 # PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis.
Sasanuma H, Nakata M, Parmila K, Nakae J, Yada T.
Mol Metab. 2017 Feb 17;6(5):428-439.

# Soy Protein Isolate Suppresses Lipodystrophy-induced Hepatic Lipid Accumulation in Model Mice.
Nagao K, Matsumoto A, Kai S, Kayashima T, Yanagita T.
J Oleo Sci. 2017 Feb 1;66(2):161-169.

# A high-fat diet temporarily renders Sod1-deficient mice resistant to an oxidative insult.
Ito J, Ishii N, Akihara R, Lee J, Kurahashi T, Homma T, Kawasaki R, Fujii J
J Nutr Biochem. 2017 Feb;40:44-52. 

# Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice.
Saito N, Kimura S, Miyamoto T, Fukushima S, Amagasa M, Shimamoto Y, Nishioka C, Okamoto S, Toda C, Washio K, Asano A, Miyoshi I, Takahashi E, Kitamura H.
Biochem Biophys Rep. 2017 Jan 26;9:322-329.

# Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease.
Watanabe H, Inaba Y, Kimura K, Asahara SI, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H.
J Nutr. 2017 Jan;147(1):52-60.

# BCL11B gene heterozygosity causes weight loss accompanied by increased energy consumption, but not defective adipogenesis, in mice
Jun Inoue, Yusuke Ihara, Daisuke Tsukamoto, Keisuke Yasumoto, Tsutomu Hashidume, Kenya Kamimura, Shigeki Hirano, Makoto Shimizu, Ryo Kominami & Ryuichiro Sato
Bioscience, Biotechnology, and Biochemistry, Vol.81, 2017,Issue 5, p922-930

# Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice.
Natsuko Saitoa,Shunsuke Kimurac,Tomomi Miyamotod,Sanae Fukushimae,Misato Amagasaa,Yoshinori Shimamotob,
Chieko Nishiokae,Shiki Okamotof,Chitoku Todag,Kohei Washioa,Atsushi Asanoh,Ichiro Miyoshid,Eiki Takahashie,Hiroshi Kitamura
Biochemistry and Biophysics Reports,Volume 9, March 2017, Pages 322-329

# Agmatine ameliorates type 2 diabetes induced-Alzheimer’s disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling.
Kang S, Kim CH, Jung H, Kim E, Song HT, Lee JE.
Neuropharmacology. 2017 Feb;113(Pt A):467-479

#Dietary nitrite reverses features of postmenopausal metabolic syndrome induced by high fat diet and ovariectomy in mice.
Ohtake K, Ehara N, Chiba H, Nakano G, Sonoda K, Ito J, Uchida H, Kobayashi J
Am J Physiol Endocrinol Metab. 2017 Feb 14

#A high-fat diet temporarily renders Sod1-deficient mice resistant to an oxidative insult.
Ito J, Ishii N, Akihara R, Lee J, Kurahashi T, Homma T, Kawasaki R, Fujii J
J Nutr Biochem. 2017 Feb;40:44-52.

#Inhibition of Gastric Inhibitory Polypeptide Receptor Signaling in Adipose Tissue Reduces Insulin Resistance and Hepatic Steatosis in High Fat Diet-Fed Mice.
Joo E, Harada N, Yamane S, Fukushima T, Taura D, Iwasaki K, Sankoda A, Shibue K, Harada T, Suzuki K, Hamasaki A, Inagaki N.
Diabetes. 2017 Jan 17. 

#BCL11B gene heterozygosity causes weight loss accompanied by increased energy consumption, but not defective adipogenesis, in mice.
Inoue J, Ihara Y, Tsukamoto D, Yasumoto K, Hashidume T, Kamimura K, Hirano S, Shimizu M, Kominami R, Sato R.
Biosci Biotechnol Biochem. 2017 Jan 9:1-9.

#Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice.
Satoko Shimazu-Kuwahara,Norio Harada,Shunsuke Yamane,Erina Joo,Akiko Sankoda,Timothy J. Kieffer,Nobuya Inagaki
Molecular Metabolism,Available online 19 January 2017

#Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease.
Watanabe H, Inaba Y, Kimura K, Asahara SI, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H
J Nutr. 2017 Jan;147(1):52-60.

#Germinated Pigmented Rice (Oryza Sativa L. cv. Superhongmi) Improves Glucose and Bone Metabolisms in Ovariectomized Rats.
Chung SI, Ryu SN, Kang MY
Nutrients. 2016 Oct 21;8(10).

#Angiopoietin-like peptide 4 regulates insulin secretion and islet morphology.
Kim HK, Kwon O, Park KH, Lee KJ, Youn BS, Kim SW, Kim MS.
Biochem Biophys Res Commun. 2017 Feb 7

#Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity.
Joo E, Fukushima T, Harada N, Reed JC, Matsuzawa SI, Inagaki N.
Sci Rep. 2016 Oct 31;6:35983.

#Procyanidin Promotes Translocation of Glucose Transporter 4 in Muscle of Mice through Activation of Insulin and AMPK Signaling Pathways.
Yamashita Y, Wang L, Nanba F, Ito C, Toda T, Ashida H.
PLoS One. 2016 Sep 6;11(9):e0161704

#Oxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells.
Watanabe S, Wei FY, Matsunaga T, Matsunaga N, Kaitsuka T, Tomizawa K.
Sci Rep. 2016 May 4;6:25185.

#Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver.
Honma K, Hikosaka M, Mochizuki K, Goda T.
Metabolism. 2016 Apr;65(4):482-91

#Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice.
Miyazaki T, Shirakami Y, Kubota M, Ideta T, Kochi T, Sakai H, Tanaka T, Moriwaki H, Shimizu M.
Oncotarget. 2016 Mar 1;7(9):10448-58.

#Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance.
Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Murata C, Kim-Kaneyama JR, Sato F, Bando M,
Yagi S, Soeki T, Hayashi T, Imoto I, Sakaue H, Shimabukuro M, Sata M
Sci Adv. 2016 Mar 25;2(3):e1501332

#Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6.
Park BK, Lee EA, Kim HY, Lee JC, Kim KS, Jeong WH, Kim KY, Ku BJ, Rhee SD.
J Diabetes Res. 2016;2016:1632061

#Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.
Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H,
Akaike T, Tomizawa K.

# Effects of caloric restriction on O-GlcNAcylation, Ca(2+) signaling, and learning impairment in the hippocampus of ob/ob mice.
Jeon BT, Heo RW, Jeong EA, Yi CO, Lee JY, Kim KE, Kim H, Roh GS.
Neurobiol Aging. 2016 Aug;44:127-37.

# Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice.
Jung MJ, Lee J, Shin NR, Kim MS, Hyun DW, Yun JH, Kim PS, Whon TW, Bae JW.
Sci Rep. 2016 Jul 29;6:30887.

# Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects.
Hashidume T, Kato A, Tanaka T, Miyoshi S, Itoh N, Nakata R, Inoue H, Oikawa A, Nakai Y, Shimizu M, Inoue J, Sato R
Sci Rep. 2016 Jun 17;6:28183.

# Paraventricular NUCB2/Nesfatin-1 Supports Oxytocin and Vasopressin Neurons to Control Feeding Behavior and Fluid Balance in Male Mice.
Nakata M, Gantulga D, Santoso P, Zhang B, Masuda C, Mori M, Okada T, Yada T.
Endocrinology. 2016 Jun;157(6):2322-32.

# Oxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells.
Watanabe S, Wei FY, Matsunaga T, Matsunaga N, Kaitsuka T, Tomizawa K
Sci Rep. 2016 May 4;6:25185.

# Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver.
Honma K, Hikosaka M, Mochizuki K, Goda T.
Metabolism. 2016 Apr;65(4):482-91.

# Protective effect of vitamin E against alloxan-induced mouse hyperglycemia.
Takemoto K, Doi W, Masuoka N.
Biochim Biophys Acta. 2016 Apr;1862(4):647-50.

# Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice.
Harada N, Hanaoka R, Horiuchi H, Kitakaze T, Mitani T, Inui H, Yamaji R.
Sci Rep. 2016 Mar 10;6:23001.

# Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization.
Take K, Mochida T, Maki T, Satomi Y, Hirayama M, Nakakariya M, Amano N, Adachi R, Sato K, Kitazaki T, Takekawa S.
PLoS One. 2016 Mar 3;11(3):e0150976.

# GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance
Naomi Nishio and Ken-ichi Isobe
Sci Rep. 2015; 5: 13519.

# Patterns of Brain Activation and Meal Reduction Induced by Abdominal Surgery in Mice and Modulation by Rikkunshito
Lixin Wang, Sachiko Mogami, Seiichi Yakabi, Hiroshi Karasawa, Chihiro Yamada, Koji Yakabi, Tomohisa Hattori, and Yvette Taché
PLoS One. 2015; 10(9): e0139325.

# Hot water extracts of edible Chrysanthemum morifolium Ramat. exert antidiabetic effects in obese diabetic KK-Ay mice
Yamamoto J, Tadaishi M, Yamane T, Oishi Y, Shimizu M, Kobayashi-Hattoria K.
Bioscience, Biotechnology, and Biochemistry, Vol.79(7), 2015.

# Dietary obacunone supplementation stimulates muscle hypertrophy, and suppresses hyperglycemia and obesity through the TGR5 and PPARγ pathway.
Horiba T, Katsukawa M, Mita M, Sato R
Biochem Biophys Res Commun. Vol.463(4), p846-52, Aug. 2015.

# Hepatic STAMP2 alleviates high fat diet-induced hepatic steatosis and insulin resistance.
Kim HY, Park SY, Lee MH, Rho JH, Oh YJ, Jung HU, Yoo SH, Jeong NY, Lee HJ, Suh S, Seo SY, Cheong J, Jeong JS, Yoo YH.
J Hepatol. Vol.63(2), p477-85, Aug 2015.

# Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo.
Kushibiki T, Okawa S, Hirasawa T, Ishihara M.
Gene Ther. Vol.22(7), p553-9, Jul 2015.

# Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice.
Ohno T, Shimizu M, Shirakami Y, Miyazaki T, Ideta T, Kochi T, Kubota M, Sakai H, Tanaka T, Moriwaki H.
Hepatol Res. Jul 2015

# Effects of liquid konjac on parameters related to obesity in diet-induced obese mice.
Aoe S, Kudo H, Sakurai S.
Biosci Biotechnol Biochem. Vol.79(7), p1141-6, Jul 2015.

# Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity.
Hwang I, Park YJ, Kim YR, Kim YN, Ka S, Lee HY, Seong JK, Seok YJ, Kim JB
FASEB J. Vol.29(6), p2397-411, Jun 2015.

# PRMT4 is involved in insulin secretion via the methylation of histone H3 in pancreatic β cells.
Kim JK, Lim Y, Lee JO, Lee YS, Won NH, Kim H, Kim HS.
J Mol Endocrinol.Vol.54(3), p315-24, Jun 2015.

# Hepatic NPC1L1 overexpression ameliorates glucose metabolism in diabetic mice via suppression of gluconeogenesis.
Kurano M, Hara M, Satoh H, Tsukamoto K.
Metabolism. Vol.64(5), p588-96, May 2015.

# Chronic high intake of quercetin reduces oxidative stress and induces expression of the antioxidant enzymes in the liver and visceral adipose tissues in mice
Kobori M, Takahashi Y, Akimoto Y, Sakurai M, Matsunaga I, Nishimuro H, Ippoushi K,  Oike H, Ohnishi-Kameyama M.
Journal of Functional Foods, Vol.15, p551–560, May 2015.

# Effects of quercetin derivatives from mulberry leaves: Improved gene expression related hepatic lipid and glucose metabolism in short-term high-fat fed mice.
Sun X, Yamasaki M, Katsube T, Shiwaku K.
Nutr Res Pract. Vol.9(2), p137-43, Apr 2015.

# Insulin Release from the Beta Cells in Acatalasemic Mice Is Highly Susceptible to Alloxan-Induced Oxidative Stress
Kazunori Takemoto, Wakana Doi, Ken Kataoka, Kohji Ishihara, Da-Hong Wang., Hitoshi Sugiyama, Noriyoshi Masuoka
JDM, Vol.5 No.2, May 2015

# Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice.
Hu H, Guo Q, Wang C, Ma X, He H, Oh Y, Feng Y, Wu Q, Gu N.
J Appl Toxicol. Mar 2015 .

# Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets.
Kanno A, Asahara S, Masuda K, Matsuda T, Kimura-Koyanagi M, Seino S, Ogawa W, Kido Y.
Biochem Biophys Res Commun. Vol.13;458(3), p681-6. Mar 2015.

# Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo.
Kushibiki T, Okawa S, Hirasawa T, Ishihara M.
Gene Ther. Mar 2015.

# Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets.
Kanno A, Asahara S, Masuda K, Matsuda T, Kimura-Koyanagi M, Seino S, Ogawa W, Kido Y.
Biochem Biophys Res Commun. Vol.458(3), p681-6, Mar 2015.

# Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.
Quan X, Nguyen TT, Choi SK, Xu S, Das R, Cha SK, Kim N, Han J, Wiederkehr A, Wollheim CB, Park KS.
J Biol Chem. Vol.290(7), p4086-96, Feb 2015.

# Endogenous Interleukin 18 Suppresses Hyperglycemia and Hyperinsulinemia during the Acute Phase of Endotoxemia in Mice.
Yamashita H, Aoyama-Ishikawa M, Takahara M, Yamauchi C, Inoue T, Miyoshi M, Maeshige N, Usami M, Nakao A, Kotani J
Surg Infect (Larchmt). 2015 Feb;16(1):90-6.

# Hot water extracts of edible Chrysanthemum morifolium Ramat. exert antidiabetic effects in obese diabetic KK-Ay mice.
Junpei Yamamoto, Miki Tadaishi, Takumi Yamane, Yuichi Oishi, Makoto Shimizu & Kazuo Kobayashi-Hattoria
Bioscience, Biotechnology, and Biochemistry, Published online: 10 Feb 2015

# Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity.
Hwang I, Park YJ, Kim YR1, Kim YN, Ka S, Lee HY, Seong JK, Seok YJ, Kim JB.
FASEB J. Feb 2015.

# Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice.
Hu H, Guo Q, Wang C, Ma X, He H, Oh Y, Feng Y, Wu Q, Gu N.
J Appl Toxicol. Mar 2015.

# Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice.
Zhang T, Yamashita Y, Yasuda M, Yamamoto N, Ashida H.
Food Funct. Vol.6(1), p134-144, Jan 2015.

# Dietary nitrite supplementation improves insulin resistance in type 2 diabetic KKAy mice
Ohtake K, Nakano G, Ehara N, Sonoda K, Ito J, Uchida H, Kobayashi J.
Nitric Oxide, Vol.44, p31–38, Jan 2015.

# Salicornia herbacea prevents weight gain and hepatic lipid accumulation in obese ICR mice fed a high-fat diet.
Pichiah PT, Cha YS.
J Sci Food Agric. Dec 2014.

# Salicornia herbacea prevents weight gain and hepatic lipid accumulation in obese ICR mice fed a high-fat diet.
Pichiah PT1, Cha YS.
J Sci Food Agric. Dec 2014.

# Salacia reticulata has therapeutic effects on obesity.
Shimada T, Nakayama Y, Harasawa Y, Matsui H, Kobayashi H, Sai Y, Miyamoto K, Tomatsu S, Aburada M.
J Nat Med. Vol.68(4), p668-676, Oct 2014.

# Ghrelin administered spinally increases the blood glucose level in mice
Sim Y-B., Park S-H., Kim S-S., Kim C-H., Kim S-J., Lim S-M., Jung J-S., Suh H-W.
Peptides, Vol.54, p162-165, Apr 2014.

# Chronic exposure to valproic acid promotes insulin release, reduces KATP channel current and does not affect Ca2+ signaling in mouse islets
Manaka K., Nakata M., Shimomura K., Rita RS., Maejima Y., Yoshida M., Dezaki K., Kakei M., Yada T.
The Journal of Physiological Sciences, Vol.64(1), p77-83, Jan 2014.

# Impaired Lipid and Glucose Homeostasis in Hexabromocyclododecane-Exposed Mice Fed a High-Fat Diet
Yanagisawa R., Koike E., Win-Shwe TT., Yamamoto M. and Takano H.
ENVIRONMENTAL HEALTH PERSPECTIVES, Jan 2014.

# Lipid-Lowering Effects of Pediococcus acidilactici M76 Isolated from Korean Traditional Makgeolli in High Fat Diet-Induced Obese Mice
Moon Y-J., Baik S-H. and Cha Y-S.
Nutrients, Vol.6(3), p1016-1028, 2014.

# Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice
Matsumoto S., Shimabukuro M., Fukuda D., Soeki T., Yamakawa K., Masuzaki H. and Sata M.
Cardiovascular Diabetology, 13:30, 2014.

# Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice
T.Tsuduki, I.Kikuchi, T.Kimura, K.Nakagawa, T.Miyazawa.
Food Chemistry, Vol.139(1-4), p16-23, Aug 2013.

# Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion
H.Tanaka, S.Yoshida, H.Oshima, H.Minoura, K.Negoro, T.Yamazaki, S.Sakuda, F.Iwasaki, T.Matsui and M. Shibasaki.
JPET, Jul 2013.

# Contribution of insulin signaling to the regulation of pancreatic beta-cell mass during the catch-up growth period in a low birth weight mouse model
Y.Yoshida, M.Fuchita, M.Kimura-Koyanagi, A.Kanno, T.Matsuda, S.Asahara, N.Hashimoto, T.Isagawa, W.Ogawa, H.Aburatani, T.Noda, S.Seino, M.Kasuga, Y.Kido.
Diabetology International, Jul 2013.

# Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle
T.Naito, A.Kuma and N.Mizushima.
The Journal of Biological Chemistry, Jun 2013.

# Apelin Inhibits Diet-Induced Obesity by Enhancing Lymphatic and Blood Vessel Integrity
M.Sawane, K.Kajiya, H.Kidoya, M.Takagi, F.Muramatsu and N.Takakura.
Diabetes, Vol.62(6), p1970-1980, Jun 2013.

# Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin
S.Asahara, Y.Shibutani, K.Teruyama, H.Y.Inoue, Y.Kawada, H.Etoh, T.Matsuda, M.Kimura-Koyanagi, N.Hashimoto, M.Sakahara, W.Fujimoto, H.Takahashi, S.Ueda, T.Hosooka, T.Satoh, H.Inoue, M.Matsumoto, A.Aiba, M.Kasuga, Y.Kido.
Diabetologia, Vol.56(5), p1088-1097, May 2013.

# Effects of hydrophilic statins on renal tubular lipid accumulation in diet-induced obese mice
K.Gotoh, T.Masaki, S.Chiba, H.Ando, K.Fujiwara, T.Shimasaki, Y.Tawara, I.Toyooka, K.Shiraishi, K.Mitsutomi, M.Anai, E.Itateyama, J.Hiraoka, K.Aoki, N.Fukunaga, T.Nawata, T.Kakuma.
Obesity Research & Clinical Practice, May 2013.

# Amyloid-β Induces Hepatic Insulin Resistance In Vivo via JAK2
Y.Zhang, B.Zhou, B.Deng, F.Zhang, J.Wu, Y.Wang, Y.Le and Q.Zhai.
Diabetes, Vol.62(4), p1159-1166, Apr 2013.

# Histidine augments the suppression of hepatic glucose production by central insulin action
Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M and Inoue H.
Diabetes, Vol.62(4), p1003-1004, Apr 2013

# Improved transplantation outcome through delivery of DNA encoding secretion signal peptide-linked glucagon-like peptide-1 into mouse islets
Chae H Y, Lee M, Hwang H J, Kim H A, Kang J G, Kim C S, Lee S J, Ihm S-H.
Transplant International, Vol.26(4), p443-452, Apr 2013.

# Histidine augments the suppression of hepatic glucose production by central insulin action
K.Kimura, Y.Nakamura, Y.Inaba, M.Matsumoto, Y.Kido, S.Asahara, T.Matsuda, H.Watanabe, A.Maeda, F.Inagaki, C.Mukai, K.Takeda, S.Akira, T.Ota, H.Nakabayashi, S.Kaneko, M.Kasuga and H.Inoue.
Diabetes, Mar 2013.

# Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice without adverse side effects
Bak E-J, Kim J-H, Lee D-E, Choi Y-H, Kim J M, Woo G-H, Cha J-H, Yoo Y-J.
Clinical Nutrition, Available online 26, Mar 2013.

# Extracellular Signal-Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle
Toda C, Shiuchi T, Kageyama H, Okamoto S, Coutinho E A, Sato T, Okamatsu-Ogura Y, Yokota S, Takagi K, Tang L, Saito K, Shioda S and Minokoshi Y.
Diabetes Mar 2013.

# Effect of vitamin E on alloxan-induced mouse diabetes
Kamimura W, Doi W, Takemoto K, Ishihara K, Wang D-H, Sugiyama H, Oda S, Masuoka N.
Clinical Biochemistry, Mar 2013.

# Ablation of Rnf213 retards progression of diabetes in the Akita mouse
Kobayashi H, Yamazaki S, Takashima S, Liu W, Okuda H, Yan J, Fujii Y, Hitomi T, Harada K H, Habu T, Koizumi A.
Biochemical and Biophysical Research Communications, Vol.432(3), p519-525, Mar 2013.

# Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice
Lee Y-S, Sasaki T, Kobayashi M, Kikuchi O, Kim H-J, Yokota-Hashimoto H, Shimpuku M, Susanti V-Y, Ido-Kitamura Y, Kimura K, Inoue H, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ohya S, Tanaka Y, Kitajima S, Kitamura T.
Diabetologia, Mar 2013.

# Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin
S. Asahara, Y. Shibutani, K. Teruyama, H. Y. Inoue, Y. Kawada, H. Etoh, T. Matsuda, M. Kimura-Koyanagi, N. Hashimoto, M. Sakahara, W. Fujimoto, H. Takahashi, S. Ueda, T. Hosooka, T. Satoh, H. Inoue, M. Matsumoto, A. Aiba, M. Kasuga, Y. Kido
Diabetologia, Feb 2013.

# Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice
Miura K, Yang L, Rooijen N, Brenner D A, Ohnishi H, Seki E.
Hepatology, Vol.57(2), p577-589, Feb 2013.

# Transcriptional Regulatory Factor X6 (Rfx6) Increases Gastric Inhibitory Polypeptide (GIP) Expression in Enteroendocrine K-cells and Is Involved in GIP Hypersecretion in High Fat Diet-induced Obesity*
K.Suzuki, N.Harada, S.Yamane, Y.Nakamura, K.Sasaki, D.Nasteska, E.Joo, K.Shibue, T.Harada, A.Hamasaki, K.Toyoda, K.Nagashima and N.Inagaki.
The Journal of Biological Chemistry, Vol.288, p1929-1938, Jan 2013.

# Improved hypothermic short-term storage of isolated mouse islets by adding serum to preservation solutions
Yasuko Kimura, Teru Okitsu, Liu Xibao, Hiroki Teramae, Atsuhito Okonogi, Kentaro Toyoda, Shinji Uemoto and Masanori Fukushima
Islets, Vol.5(1), Jan 2013.

# Anti-diabetic effect of amorphastilbol through PPARα/γ dual activation in db/db mice
Lee W, Ham J, Kwon H C, Kim Y K, Kim S-N.
Biochemical and Biophysical Research Communications, Jan 2013.

# Transcriptional Regulatory Factor X6 (Rfx6) Increases Gastric Inhibitory Polypeptide (GIP) Expression in Enteroendocrine K-cells and Is Involved in GIP Hypersecretion in High Fat Diet-induced Obesity
Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, Joo E, Shibue K, Harada T, Hamasaki A,Toyoda K, Nagashima K and Inagaki N.
The Journal of Biological Chemistry, Vol.288, p1929-1938, Jan 2013.

# Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity
Sawane M, Kajiya K, Kidoya H, Takagi M, Muramatsu F and Takakura N.
Diabetes, 2013.

# Beneficial effects of Allium sativum L. stem extract on lipid metabolism and antioxidant status in obese mice fed a high fat diet
Kim I, Kim H-R, Kim J-H, Om A-S.
Journal of the Science of Food and Agriculture, 2013..

# Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice
Tsuduki T, Kikuchi I, Kimura T, Nakagawa K, Miyazawa T.
Food Chemistry, Vol.139(14), p16-23, 2013.

# Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob/ob mice
Inoue N, Inafuku M, Shirouchi B, Nagao K and Yanagita T.
Lipids in Health and Disease, Vol.12(18), 2013.

# Pax6 Directly Down-Regulates Pcsk1n Expression Thereby Regulating PC1/3 Dependent Proinsulin Processing
Liu T., Zhao Y., Tang N., Feng R., Yang X., Lu N., Wen J., Li L.
PLOS ONE, Vol.7(10), Oct 2012.

# Anti-Diabetic Atherosclerosis Effect of Prunella vulgaris in db/db Mice with Type 2 Diabetes
Hwang S M, Kim J K, Lee Y J, Yoon J J, Lee S M, Kang D G, Lee H S.
Am J Chin Med, Vol.40, 2012.

# Prevention mechanisms of glucose intolerance and obesity by cacao liquor procyanidin extract in high-fat diet-fed C57BL/6 mice
Y. Yamashita., M. Okabe., M. Natsume., H. Ashida.
Archives of Biochemistry and Biophysics, Available online 23 March 2012, In Press

# The Action of D-Dopachrome Tautomerase as an Adipokine in Adipocyte Lipid Metabolism
T. Iwata., H. Taniguchi., M. Kuwajima., T. Taniguchi., Y. Okuda., A. Sukeno., K. Ishimoto., N. Mizusawa., K. Yoshimoto.
PLos ONE, Vol. 7(3), Mar 2012.

# Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice
Y. Yamada.,.A. Muraki.,.M. Oie.,.N. Kanegawa.,.A. Oda., Y. Sawashi., K. Kaneko., M. Yoshikawa., T. Goto., N. Takahashi., T. Kawada., and K. Ohinata.
American Physiological Society, Vol.302, No.4, E433-E440, 2012.

# Effects of Gametophytes of Ecklonia Kurome on the Levels of Glucose and Triacylglycerol in db/db, Prediabetic C57BL/6J and IFN-γ KO Mice
F. Dwiranti., M. Hiraoka., T. Taguchi., Y. Konishi., M. Tominaga., A. Tominaga.
Int J B 64 iomed Sci, Vol.8, No.1, Mar 2012.

# Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphprylation and Deacetylation
K. Kimura., T. Yamada., M. Matsumoto., Y. Kido., T. Hosooka., S. Asahara., T. Matsuda., T. Ota., H. Watanabe., Y. Sai., K. Miyamoto., S. Kaneko., M. Kasuga., H. Inoue.
Diabetes, Vol.61, No.1, p61-73, 2012.

# Melatonin protects mice with intermittent hypoxia from oxidative stress-induced pancreatic injury
LI G., HOU G., LU W., KANG J.
Sleep and Biological Rhythms, Vol.9(2), p78-85, Apr 2011.

# A novel dipeptidyl peptidase IV inhibitor DA-1229 ameliorates streptozotocin-induced diabetes by increasing β-cell replication and neogenesis
J, M, Cho., H, W, Jang., H, Cheon.,Y, T, Jeong., D-H, Kim., Y-M, Lim., S, Choi., E, Yang., C-Y, Shin., M, H, Son., S, H, Kim., H, Kim., M, Lee.
Diabetes Research and Clinical Practice.Vol. 91(1), p72-79, 2011.

# Effect of astragaloside IV on hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin
Lv L., Wu S-Y., Wang G-F., Zhang J-J., Pang J-X., Liu Z-Q., Xu X., Wu S-G., Rao J-J.
Phytotherapy Research, Vol.24(2), p219-224, Feb 2010.

# Eicosapentaenoic acid improves hepatic steatosis independent of PPAR [alpha] activation through inhibition of SREBP-1 maturation in mice
N. Tanaka., X. Zhang., E. Sugiyama., H. Kono., A. Horiuchi., T. Nakajima., H. Kanbe., E. Tanaka., F. J. Gonzalez., T. Aoyama
Biochemical Pharmacology Vol.80(10), p1601-1612, 2010

# The Murine Glucagon-Like Peptide-1 Receptor Is Essential for Control of Bone Resorption
C, Yamada., Y, Yamada., K, Tsukiyama., K, Yamada., N, Udagawa., N, Takahashi., K, Tanaka., D, J, Drucker., Y, Seino., and N, Inagaki
Endocrinology. Vol.149, No. 2, p574-579, 2008.

# Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion
M, Morishita., T, Tanaka., T, Shida., K, Takayama.
Journal of Controlled Release.Vol. 132(2), p99-104, 2008.

# Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin
T, Adachi., T, Tanaka., K, Takemoto., T, Koshimizu., A, Hirasawa., G, Tsujimoto.
Biochemical and Biophysical Research Communications.Vol.340(1), p332-337, 2006.

# Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1
M, Koizumi., R, Doi., K, Fujimoto., D, Ito., E, Toyoda., T, Mori., K, Kami.,Y, Kawaguchi., G, K, Gittes., M, Imamura.
Surgery.Vol.138(2), p125-133, 2005.

# Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
A, Suzuki., H, Nakauchi., and H, Taniguchi.
PNAS,  Vol.100, No.9, p5034-5039, Apr 2003.

# Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver
Y.Toyoshima., R.Tokita., Y.Ohne., F.Hakuno., T.Noguchi., S.Minami., H.Kato., and S.Takahashi.
Journal of Molecular Endocrinology. Vol.47(1), 2011.

# Sorting nexin 19 regulates the number of dense core vesicles in pancreatic β-cells
S. Harashima., T. Horiuchi., Y. Wang., A. L. Notkins., Y. Seino., N. Inagaki.
Journal of Diabetes Investigation.published online: 28 JUN 2011

# Synergistic improvement in insulin resistance with a combination of fenofibrate and rosiglitazone in obese type 2 diabetic mice
W.S.Choi., J.J.Lee., Y. Kim., I.S. Kim., W.Y. Zhang., and C.S. Myung.
Archives of Pharmacal Research .Vol.34(4), p615-624, 2011

# Preventive Effect of Boiogito on Metabolic Disorders in the TSOD Mouse, a Model of Spontaneous Obese Type II Diabetes Mellitus
T. Shimada., T. Akase., M. Kosugi., and M. Aburada.
Evidence-Based Complementary and Alternative Medicine.Volume 2011.

# Preventive Effect of Pine Bark Extract (Flavangenol) on Metabolic Disease in Western Diet-Loaded Tsumura Suzuki Obese Diabetes Mice
T. Shimada., M. Kosugi., D. Tokuhara., M. Tsubata., T. Kamiya., M. Sameshima., R. Nagamine., K. Takagaki., K. Miyamoto., and M. Aburada.
Evidence-Based Complementary and Alternative Medicine.Volume 2011.

# Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice
T. Akase., T. Shimada., Y. Harasawa., T. Akase., Y. Ikeya., E. Nagai., S.Iizuka., G. Nakagami., S. Iizaka., H. Sanada.,and M. Aburada.
Evidence-Based Complementary and Alternative Medicine.Volume 2011.

# Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat Diet
N. Ikarashi., T. Toda., T. Okaniwa., K. Ito., W.Ochiai., and K. Sugiyama.
Evidence-Based Complementary and Alternative Medicine.Volume 2011.

# Preventive effects of Salacia reticulata on non-alcoholic fatty liver disease (NAFLD)/ non-alcoholic steatohepatitis (NASH) in monosodium glutamate treated mice
M. Watanabe., T. Shimada., S. Iiduka., N. Iida., K. Kojima., J. Ishizaki., Y. Sai., K. Miyamoto., and M. Aburada.
Journal of Traditional Medicines .Vol. 28 (2011) , No. 2 pp.73-82

# Effects of antidiabetic drugs in high-fat diet and streptozotocin-nicotinamide-induced type 2 diabetic mice
A. Tahara., A. Matsuyama-Yokono., and M. Shibasaki.
European Journal of Pharmacology.Vol.655(1-3), p108-116. 2011.

# Preventive Effects of (-)-Epigallocatechin Gallate on Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BL/KsJ-db/db Mice
M. Shimizu., H.Sakai, Y.Shirakami., Y.Yasuda., M.Kubota., D.Terakura., A. Baba., T.Ohno., Y.Hara., T. Tanaka., and H. Moriwaki.
Cancer Prev Res; Vol.4(3); p396-403. 2011 AACR

# Dietary Aloe Improves Insulin Sensitivity via the Suppression of Obesity-induced Inflammation in Obese Mice
E. Shin., K.S.Shim., H. Kong., S.Lee., S. Shin., J. Kwon., T.H.Jo., Y-I. Park., C-K. Lee., and K. Kim.
Immune Network. Vol.11(1), p59-67.2011

# Expression of CD38 with intracellular enzymatic activity: a possible explanation for the insulin release induced by intracellular cADPR
Y. Ohta., A. Kitanaka., K. Mihara., O. Imataki., H. Ohnishi., T. Tanaka., T. Taminato., and Y. Kubota.
Molecular and Cellular Biochemistry .Vol.352, Numbers 1-2, p293-299, 2011.

# Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer’s-like phenotypes in mice
K. Murakami., S. Yokoyama., N. Murata., Y. Ozawa., K. Irie., T. Shirasawa., and T. Shimizu.
Biochemical and Biophysical Research Communications.Vol.409(1), p34-39, 2011.

# Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist
H. Tanaka., A. Shimaya., T. Kiso., T. Kuramochi., T. Shimokawa., and M. Shibasaki.
Life Sciences.Vol.88(11-12), p559-563, 2011.

# Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line
K. Yamagata., T. Senokuchi., M. Lub., M. Takemoto., M.D. F. Karim., C. Go., Y. Sato., M. Hatta., T. Yoshizawa., E. Araki., J. Miyazaki. and W-J. Song.
Biochemical and Biophysical Research Communications.Vol.407(3), p620-625, 2011.

# Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice
E. Naito., Y. Yoshida., K. Makino., Y. Kounoshi., S. Kunihiro., R. Takahashi., T. Matsuzaki., K. Miyazaki., F. Ishikawa.
Journal of Applied Microbiology.Vol.110(3), p650-657, 2011.

# Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity.
S. Kondo., J.Z. Xiao., T. Satoh., T. Odamaki., S. Takahashi., H. Sugahara., T. Yaeshima., K. Iwatsuki., A. Kamei., K. Abe.
Biosci Biotechnol Biochem. Vol.74(8), p1656-61, 2010.

# Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin
Wu S.,Wang G.,Liu Z., Rao J., LU L., Xu W., Wu S. and Zhang J.
Acta Pharmacologica Sinica, Vol.30(12), p202-208, Feb 2009.

# Dose dependent development of diabetes mellitus and non-alcoholic steatohepatitis in monosodium glutamate-induced obese mice
Sasaki,Y.,Suzuki,W.,Shimada,T.,Iizuka,S.,Nakamura,S.,Nagata,M.,Fujimoto,M.,
Tsuneyama,K.,Hokao,R.,Miyamoto,K.,Aburada,M.
Life Sciences 85,490-498, 2009.

# Preventive Effect of Boiogito on Metabolic Disorders in the TSOD Mouse, a Model of Spontaneous Obese Type II Diabetes Mellitus.
Shimada, T., Akase, T., Kosugi, M., and Aburada, M.
eCAM Advance Access, p1-8, 2009.

# Transgenic expression of a mutated cyclin-dependent kinase 4(CDK4/R24G)  in pancreatic β-cells prevents progression of diabetes in db/db mice
Miyawaki,K.,Inoue,H.,Keshavarz,P.,Mizuta,K.,Sato,A.,Sakamoto,Y.,Moritani,M., Kunika,K.,Tanahashi,T.and Itakura,M.
Diabetes Research and Clinical Practice 82, p33-41, 2008.

# Abdominal Irradiation Ameliorates Obesity in ob/ob Mice
Okada, S., Kobayashi, K., Ishikawa, M., Inoue, N., Yamada, N. and Shimano, H.
J Clin Biochem Nutr, Vol.40(2), p123-130, Mar 2007.

# Agent for Preventing Metabolic Syndrome .
Okada,Y., and Iio, K.
US Patent App. 11/567, 038, 2006

# Differentiation of embryonic stem cells into insulin-producing cells promoted by Nkx2.2 gene transfer
Shiroi, A., Ueda, S., Ouji, Y., Saito, K., Moriya, K., Sugie, Y., Fukui, H., Ishizaka, S., Yoshikawa, M.
World J Gastroenterol, Vol.11(27), p4161-4166, 2005.

# PKClregulates glucose-induced insulin secretion through modulation of gene expression in pancreatic ß cells
Hashimoto, N., Kido, Y., Uchida, T., Matsuda, T., Suzuki, K., Inoue, H., Matsumoto, M., Ogawa, W., Maeda, S., Fujihara, H., Ueta, Y., Uchiyama, Y., Akimoto, K., Ohno, S., Noda, T., and Kasuga, M.
J. Clin. Invest. Vol.115, p138-145, 2005.

# Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., and Shimomura, I.
J. Clin. Invest. Vol.114, p1752-1761, 2004.

# A Novel Selective Peroxisome Proliferator-Activated Receptor Agonist, 2-Methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), Potently Decreases Plasma Triglyceride and Glucose Levels and Modifies Lipoprotein Profiles in KK-Ay Mice
Kuwabara, K., Murakami, K., Todo, M., Aoki, T., Asaki, T., Murai, M., and Yano, J.
J Pharmacol Exp Therapeutics Vol.309, p970-977, 2004.

# A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program
Inoue, M., Sakuraba, Y., Motegi, H., Kubota, N., Toki, H., Matsui, J., Toyoda, Y., Miwa, I., Terauchi, Y., Kadowaki, T., Shigeyama, Y., Kasuga, M., Adachi, T., Fujimoto, N., Matsumoto, R., Tsuchihashi, K., Kagami, T., Inoue, A., Kaneda, H., Ishijima, J., Masuya, H., Suzuki, T., Wakana, S., Gondo, Y., Minowa, O., Shiroishi, T., and Noda, T.
Human Molecular Genetics Vol.13, p1147-1157, 2004.

# Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity*
Tsuchida, A., Yamauchi, T., Ito, Y., Hada, Y., Maki, T., Takekawa, S., Kamon, J., Kobayashi, M., Suzuki, R., Hara, K., Kubota,N., Terauchi, Y., Froguel, P., Nakae, J., Kasuga, M., Accili, D., Tobe, K., Ueki, K., Nagai, R., and Kadowaki, T.
J. Biol. Chem., Vol. 279(29), p30817-30822, 2004.

# Identification of Insulin-Producing Cells Derived from Embryonic Stem Cells by Zinc-Chelating Dithizone
Shiroi, A., Yoshikawa, M., Yokota, H., Fukui, H., Ishizaka, S., Tatsumi, K., and Takahashi, Y.
Stem Cells, Vol.20, p284-292, 2002.

# Susceptibility and Negative Epistatic Loci Contributing to Type 2 Diabetes and Related Phenotypes in a KK/Ta Mouse Model
Shike, T., Hirose, S., Kobayashi, M., Funabiki, K., Shirai, T., and Tomino, Y.
Diabetes, Vol.50, p1943-1948, 2001.

Presentations at scientific meetings
# Significance of Circulating Ghrelin (Active and Inactive) in the Progression of
Renal Injury in Diabetes Mellitus and In Non-Smooth Muscle Calponin (Calponin-h2) Transgenic Mice
41st Annual Meeting & Scientific Exposition(第41回アメリカ腎臓学会)November 4 – 9, 2008
Pennsylvania Convention Center Philadelphia, Pennsylvania

 

 

レビス インスリン-マウス(Hタイプ)  (AKRIN-011H) / Mouse Insulin ELISA KIT (H-type)

Original reports 

# ChREBP Reciprocally Regulates Liver and Plasma Triacylglycerol Levels in Different Manners.
Iizuka K, Takao K, Kato T, Horikawa Y, Takeda J.
Nutrients. 2018 Nov 7;10(11). pii: E1699.

# A New 2-Step Acceleration Protocol Using a Histone Deacetylase Inhibitor to Generate Insulin-Producing Cells From Adipose-Derived Mesenchymal Stem Cells.
Ikemoto T, Feng R, Shimada M, Saito Y, Iwahashi S, Morine Y, Imura S.
Pancreas. 2018 Apr;47(4):477-481.
PMID: 29517636

# Does a Treadmill Running Exercise Contribute to Preventing Deterioration of Bone Mineral Density and Bone Quality of the Femur in KK-Ay Mice, a Type 2 Diabetic Animal Model?
Takagi S, Yamashita T, Miura T.
Calcif Tissue Int. 2017 Aug 4. 

# Further characterization of diabetes mellitus and body weight loss in males of the congenic mouse strain DDD. Cg-Ay
Suto J, Satou K.
The Journal of Veterinary Medical Science, 2015.

# Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation.
Wu W, Tsuchida H, Kato T, Niwa H, Horikawa Y, Takeda J, Iizuka K.
Biochem Biophys Res Commun. Vol.461(4), p681-6, Jun 2015.

# C-C Chemokine Receptor 2 Inhibitor Ameliorates Hepatic Steatosis by Improving ER Stress and Inflammation in a Type 2 Diabetic Mouse Model.
Kim HM, Lee ES, Lee BR, Yadav D, Kim YM, Ko HJ, Park KS, Lee EY, Chung CH.
PLoS One. 2015 Mar 27;10(3):e0120711.

# Viability and functional assessment of murine pancreatic islets after transportation between Korea and Japan.
Lee S, Takahashi Y, Lee KM, Mizuno M, Nemeno JG, Takebe T, Lee JI.
Transplant Proc. Vol.47(3), p738-41, Apr 2015.

# Calorie restriction-mediated restoration of hypothalamic signal transducer and activator of transcription 3 (STAT3) phosphorylation is not effective for lowering the body weight set point in IRS-2 knockout obese mice
Satoko Senda,  Atsushi Inoue,  Arshad Mahmood,  Ryo Suzuki,  Nozomu Kamei,  Naoto Kubota,  Taku Watanabe,  Masashi Aoyama,  Allah Nawaz,  Yoshiaki Ohkuma,  Koichi Tsuneyama,  Yukiko Koshimizu,  Isao Usui,  Kumiko Saeki,  Takashi Kadowaki,  Kazuyuki Tobe
Diabetology International February 2015

# Overweight in Mice and Enhanced Adipogenesis In Vitro are Associated with Lack of the Hedgehog Coreceptor Boc.
Lee HJ, Jo SB, Romer AI, Lim HJ, Kim MJ, Koo SH, Krauss RS, Kang JS
Diabetes. 2015 Jan 9.

# Investigating the suspension culture on aggregation and function of mouse pancreatic β-cells
K.-C.Yang, C.-C.Wu, S.-H.Yang, C.-C.Chiu, S.Sumi, H.-S. Lee.
Journal of Biomedical Materials Research Part A, Vol.101A(8), p2273-2282, Aug 2013.

# Microenvironment-regulated gene expression, morphology, and in vivo performance of mouse pancreatic β-cells
Chen P-Y., Wu C-C., Lu D-H., Sumi S., Lin F-H., Yange K-C.
Process Biochemistry, Vol.48(1), p58-67, Jan 2013.

# The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells
T.Matsumoto,K.Sakurai, A.Tanaka, T.Ishibashi, K.Tachibana, K.Ishikawa, K.Yokote.
European Journal of Pharmacology, Vol.685(1-3), p213-217, Jun 2012.

# Cell coupling regulates Ins1, Pdx-1 and MafA to promote insulin secretion in mouse pancreatic beta cells
K.-C. Yanga., Z. Qi., G. Yanai., Y. Shirouza., D.-H. Lu., H.-S. Lee., S. Sumi.
Process Biochemistry, Vol.46(9), p1853-1860, 2011.

# Dietary Combination of Fish Oil and Taurine Decreases Fat Accumulation and Ameliorates Blood Glucose Levels in Type 2 Diabetic/Obese KK-Ay Mice
N. Mikami., M. Hosokawa., K. Miyashita.
Journal of Food Science, Vol. 77(6), pH114-H120, Jun 2012.

# Cell coupling regulates Ins1, Pdx-1 and MafA to promote insulin secretion in mouse pancreatic beta cells
K.C. Yang., Z. Qi., G. Yanai., Y. Shirouza., D.H. Lu., H.S. Lee., and S. Sumi.
Process Biochemistry.

 

 

レビス インスリン-マウス(Sタイプ)  (AKRIN-011S) / Mouse Insulin ELISA KIT (S-type)

Original reports

# Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents development of atherosclerosis in high-fat diet-fed apoE-deficient mice via ameliorating hyperlipidemia, pro-inflammatory mediators and oxidative responses.
Kobayashi Y, Inagawa H, Kohchi C, Kazumura K, Tsuchiya H, Miwa T, Okazaki K, Soma GI.
PLoS One. 2018 Mar 27;13(3):e0195008.

# Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet.
Zang Y, Igarashi K, Yu C.
Biosci Biotechnol Biochem. Vol.79(1), p117-23, 2015.

# Roles of hepatic glucokinase in intertissue metabolic communication: Examination of novel liver-specific glucokinase knockout mice.
Hayashi H, Sato Y, Li Z, Yamamura K, Yoshizawa T, Yamagata K.
Biochem Biophys Res Commun.Vol.460(3), p727-32, May 2015.

# The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice.
Zang Y, Zhang L, Igarashi K, Yu C.
Food Funct. Vol.6(3), p834-41, Mar 2015.

#The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice.
Zang Y, Zhang L, Igarashi K, Yu C.
Food Funct. 2015 Mar 11;6(3):834-41.

#Roles of hepatic glucokinase in intertissue metabolic communication: Examination of novel liver-specific glucokinase knockout mice.
Hayashi H, Sato Y, Li Z, Yamamura KI, Yoshizawa T, Yamagata K.
Biochem Biophys Res Commun. 2015 Mar 24. pii: S0006-291X(15)00553-7.

# Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet
Zang Y, Igarashi K, Yu C.
Bioscience, Biotechnology, and Biochemistry. Vol.79(1), 2015.

# γ-Glutamyl carboxylase in osteoblasts regulates glucose metabolism in mice.
Shiba S, Ikeda K, Azuma K, Hasegawa T, Amizuka N, Horie-Inoue K, Inoue S.
Biochem Biophys Res Commun.Vol.453(3), p350-355. Oct 2014.

# Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice
Maeda A., Kai K., Ishii M., Ishii T. and Akagawa M.
Molecular Nutrition & Food Research, 2014.

# Anti-Diabetic Effects of a Kaempferol Glycoside-Rich Fraction from Unripe Soybean (Edamame,Glycine max L.Merrill.’Jindai’) Leaves on KK-Ay Mice
Y. Zang., H. Sato., K. Igarashi.
Biosci.Biotechnol.Biochem, Vol.75(9), p1677-1684, 2011.

 

 

レビス インスリン-マウス(Uタイプ)  (AKRIN-031) / Mouse Insulin ELISA KIT (U-type)

Original reports
# Prmt7 Deficiency Causes Reduced Skeletal Muscle Oxidative Metabolism and Age-Related Obesity.
Jeong HJ, Lee HJ, Vuong TA, Choi KS, Choi D, Koo SH, Cho SC, Cho H, Kang JS.
Diabetes. 2016 Jul;65(7):1868-82.

# Effect of Burdock Root and the Fermented Product on Alloxan-Induced Mouse Hyperglycemia
Doi W, Asada Y, Ohno A, Okuda Y, Masuda S, Matsumoto A, Mori C, Agarie T, Ishihara K, Murakami T, Masuoka N
Journal of Food Research, Vol4(4), 2015.

# Sympathetic Nerve Activity Maintains an Anti-inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages.
Tang L, Okamoto S, Shiuchi T, Toda C, Takagi K, Sato T, Saito K, Yokota S, Minokoshi Y.
Endocrinology. Jul 2015.

# Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc.
Lee HJ, Jo SB, Romer AI, Lim HJ, Kim MJ, Koo SH, Krauss RS, Kang JS.
Diabetes. Vol.64(6), p2092-103, Jun 2015.

# Calorie restriction-mediated restoration of hypothalamic signal transducer and activator of transcription 3 (STAT3) phosphorylation is not effective for lowering the body weight set point in IRS-2 knockout obese mice
Satoko Senda,  Atsushi Inoue,  Arshad Mahmood,  Ryo Suzuki,  Nozomu Kamei,  Naoto Kubota,  Taku Watanabe,
Aoyama M, Nawaz A, Ohkuma Y, Tsuneyama K, Koshimizu Y, Usui I, Saeki K,  Kadowaki T, Tobe K.
Diabetology International , Feb 2015.

# Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity.
Yoshida H, Watanabe H, Ishida A, Watanabe W, Narumi K, Atsumi T, Sugita C, Kurokawa M.
Biochem Biophys Res Commun. Vol.454(1), p95-101, Oct 2014.

# Disrupted daily light?dark cycle induces the expression of hepatic gluconeogenic regulatory genes and hyperglycemia with glucose intolerance in mice
K.Oishi, N.Itoh.
Biochemical and Biophysical Research Communications, Vol.432(1), p111-115, Mar 2013.

# Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice

Y.-S. Lee., B.-Y. Cha., S.-S. Choi., Y. Harada., B.-K. Choi., T. Yonezawa., T. Teruya., K. Nagai., J.-T. Woo.
BioFactors, 2012.

# Chronic administration of DSP-7238, a novel, potent, specific and substrate-selective DPP IV inhibitor, improves glycaemic control and β-cell damage in diabetic mice
Y. Furuta., M. Horiguchi., E. Sugaru., M. Ono-Kishino., M. Otani., M. Sakai., Y. Masui., A. Tsuchida., Y. Sato., K. Takubo., H. Hochigai., H. Kimura., H. Nakahira., T. Nakagawa., M. Taiji.
Diabetes, Obesity and Metabolism, Vol.12(5), p421-430, 2010.

# LOSS OF GRANUPHILIN AND OF SYNTAXIN-1A CAUSE DIFFERENTIAL EFFECTS ON INSULIN GRANULE DOCKING AND FUSION
H. Wang., R. Ishizaki., E. Kobayashi., T. Fujiwara., K. Akagawa., and T.Izumi1.
The Journal of Biological Chemistry. Vol.286(31), 2011.

# Rapid Rehydration and Moderate Plasma Glucose Elevation by Fluid Containing Enzymatically Synthesized Glycogen
K. Inagaki., K. Ishihara., M. Ishida., A. Watanabe., M. Fujiwara., Y. Komatsu., M. Shirai., Y. Kato., A. Takanezawa., T. Furuwashiki., H. Takata., and Y. Seyama.
Journal of Nutritional Science and Vitaminology.Vol.57(2011), No.2, p.170-176.

# Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes
S. Mitsutake., K. Zama., H. Yokota.,T. Yoshida., M. Tanaka., M. Mitsui., M. Ikawa., M. Okabe., Y. Tanaka., T. Yamashita., H. Takemoto., T. Okazaki., K. Watanabe., and Y. Igarashi.
The Journal of Biological Chemistry, Vol.286(31), 2011.

# Distinct Effects of Leptin and a Melanocortin Receptor Agonist Injected Into Medial Hypothalamic Nuclei on Glucose Uptake in Peripheral Tissues
C. Toda., T. Shiuchi., S. Lee., M. Yamato-Esaki., Y. Fujino., A. Suzuki., S. Okamoto., and Y. Minokoshi.
Diabetes, Vol.58, No.12, p2757-2765, Dec 2009.

# Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice
A. Fukuda., Y. Kawaguchi., K. Furuyama., S. Kodama., M. Horiguchi., T. Kuhara., M. Kawaguchi., M. Terao., R. Doi., C. V. E. Wright., M. Hoshino., T. Chiba., and S. Uemoto.
Diabetes, Vol.57, No.9, p2421-2431, Sep 2008.

# PPARαactivation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice.
Tanaka, N., Moriya, K., Kiyosawa, K., Koike, K., Gonzalez, F.J. and Aoyama, T.
J Clin Invest, Vol.118, p683-694, 2008.

# Transgenic expression of a mutated cyclin-dependent kinase 4(CDK4/R24G) in pancreatic β-cells prevents progression of diabetes in db/db mice
Miyawaki,K.,Inoue,H.,Keshavarz,P.,Mizuta,K.,Sato,A.,Sakamoto,Y.,Moritani,M., Kunika,K.,Tanahashi,T.and Itakura,M.
Diabetes Research and Clinical, Vol.82, p33-41, 2008.

# Hypoglycemic effects of exopolysaccharides produced by mycelial cultures of two different mushrooms Tremella fuciformis and Phellinus baumii in ob/ob mice.
Cho, E.J., Hwang, H.J., Kim, S.W., Oh , J.Y., Baek, Y.M., Choi, J.W., Bae, S.H., and Yun, J.W.
Applied Microbiol Biotechnol, Vol.75, p1257-1265, 2007.

# Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins.
Jin, W., Takagi, T., Kanesashi, S., Kurahashi, T., Nomura, T., Harade, J., and Ishii, S.
Developmental Cell, Vol.10, p461-471, 2006.

# Chromosome 2 locus Nidd5 has a potent effect on adiposity in the TSOD mouse .
Mizutani, S., Gomi, H., Hirayama, I., and Izumi, T.
Mammalian Genome Vol.17, p375-387, 2006.

# Granuphilin molecularly docks insulin granules to the fusion machinery.
Gomi, H., Mizutani, S., Kasai, K., Itohara, S., and Izumi, T.
J. Cell Biol, Vol.171, p99-109, 2005.

# Glucose intolerance in young TallyHo mice is induced by leptin-mediated inhibition of insulin secretion.
Sung, Y.Y., Lee, Y.S., Jung, W.H., Kim, H.G. Cheon, H., Hyae, G.C., Yang, S.D., and Sang, D.R.
Biochem Biophys Res Commun, Vol.338, p1779-1787, 2005.

# Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation
Kasai, K., Ohara-Imaizumi, M., Takahashi, N., Mizutani, S., Zhao, S., Kikuta, T., Kasai, H., Nagamatsu, S., Gomi, H., and Izumi, T.
J Clin Invest. Vol.115(2), p388-396, 2005.

# A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program
Inoue, M., Sakuraba, Y., Motegi, H., Kubota, N.,, Toki, H., Matsui, J., Toyoda, Y., Miwa, I., Terauchi, Y., Kadowaki, T., Shigeyama, Y., Kasuga, M., Adachi, T., Fujimoto, N., Matsumoto, R., Tsuchihashi, K., Kagami, T., Inoue, A., Kaneda, H., Ishijima, J., Masuya, H., Suzuki, T., Wakana, S., Gondo, Y., Minowa, O., Shiroishi, T., and Noda, T.
Human Molecular Genetics, Vol.13, p1147-1157, 2004.

# Effects of malted barley extract and banaba extract on blood glucose levels in genetically diabetic mice.
Hong, H., and Maeng W.J.
J Med Food, Vol.7, p487-490, 2004.

# Relationship between the preference for Sake (Japanese rice wine) and the movements of metabolic parameters coinciding with sake intake.
Manabe, Y., Utsunomiya, H., Gotoh, K., Kurosu, T., and Fushiki, T.
Bioscience Biotechnology and Biochemistry, Vol.68, p796-802, 2004.

# Gastric inhibitory polypeptide is the major insulinotropic factor in KATP null mice
Tsukiyama, K., Yamada Y., Miyawaki, K., Hamasaki, A., Nagashima, K., Hosokawa, M., Fujimoto, S., Takahashi, A., Toyoda, K., Toyokuni, S., Oiso, Y., and Seino Y.
European J. Endocrinol, Vol.151, p407-412, 2004.

# Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver
Miyake, K., Ogawa, W., Matsumoto, M., Nakamura, T., Sakaue, H., and Kasuga, M.
J. Clin. Invest. Vol.110, p1483-1491, 2002.

Presentations at scientific meetings
# 1st phase of glucose-stimulated insulin secretion (GSIS) consists of KATP channel-dependent and -independent pathways
Makoto shigeto, Masashi Katsura, Seitaro Ohkuma, and Kohei Kaku (Dept.Med.,KawasakiMED.Univ.,dept. Pharmacol, Kawasaki Med. Univ.)
第78回日本薬理学会年会,2005

# マウス胎児膵を用いた膵内分泌前駆細胞の培養系の確立とインスリン分泌細胞への分化
宮脇 一真,南 幸太郎,奥野 正顕,石塚 伸子,清野 進 (京都大学医学部,神戸大学大学院医学系研究科)
第48回日本糖尿病学会年次学術集会,2005年5月,糖尿病 Vol. 48, Supplement 2, p.S-108, 2005.